Adverse Reactions Due to Drug Interactions
The list of drug interactions is ever increasing and very soon, for intelligent bedside therapeutics, we may require computer technology providing adequate data storage and quick retrieval of relevant information (Hill, Spicer & Weatherall, 1968). A handbook of drug interactions catalogues, in an alphabetical index, a formidable list of interactions (Swidler, 1971)). For rational and safe therapy, the medical students, the residents and the practicing doctors must be
aware of probable drug interactions.
The whole 6 pages article is available for download here.
ADVERSE REACTIONS DUE TO DRUG INTERACTIONS
Shanti Bhushan Mishra, Kiran Prajapati*
Department of Pharmacognosy
Vinayaka Mission's College of pharmacy, Salem (T.N.) India
The list of drug interactions is ever increasing and very soon, for intelligent bedside therapeutics, we may require computer technology providing adequate data storage and quick retrieval of relevant information (Hill, Spicer & Weatherall, 1968). A handbook of drug interactions catalogues, in an alphabetical index, a formidable list of interactions (Swidler, 1971)). For rational and safe therapy, the medical students, the residents and the practicing doctors must be aware of probable drug interactions. An active educational program, organized by clinical pharmacology divisions in medical colleges, would be of an immense help in cultivating rational therapeutic practice (Sjoqvist, 1968). It is essential that drug interactions must, as a subcategory, be separately considered for cumentation, analysis and reporting by the agencies monitoring adverse drug reactions (Westerholm, 1972). Such a vigilant and discriminated monitoring can only help in the discovery of new adverse drug interactions and an evaluation of their incidence. During the administration of every new drug, a careful documentation of the concurrently given drugs can also assist in evaluation of adverse drug interactions (Hunter, Stem & Laurence, 1970). The classification of drug interactions is often based on the mechanisms involved either pharmacokinetic or pharmacodynamic factors (Karandikar, 1973). The clinician, though helped in his basic understanding by such a pharmacological classification of drug interactions, would be inclined to appreciate a more clinical approach to drug interactions. When two drugs A and B interact, the individual components of therapeutic response - A ane B may get enhanced (+) or may be diminished (-)
The whole 6 pages article is available for download here.