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The Death Gene

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Description

The cell


A Novel Means of Greatly Extending Lifespan and Resistance to Oxidative Stress


Ten fold increase in lifespan is observed for the deletion of a single gene


The findings in C. elegans are that the deletion of a specific domain of the phosphoinositol-3-kinase (PI3K) gene results in a 10-fold increase in life span.


This pathway, and this gene, is known to limit lifespan on C. elegans and, with lesser evidence, thought to affect life span in dipteran insects and mammals. The significance of the PI3K deletion rather than the mutations affecting the gene opens novel opportunities for impacting life span.


Current studies implicate the elimination of residual inositol-3,4,5-kinase activity as a possible key factor, and also suggest other directions for investigation that may lead to improvements beyond those within our ability to genetically or pharmacologically extend life span.


Ongoing research seeking insight into the utilization of these findings.


Development status


Early Stage

Patent information



U.S. Provisional Patent pending Conversion to Utility Patent



Type of business relationship sought



Seeking partner to develop and commercialize this technology


Licensing Status


Available for exclusive licensing



 

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