Formulation and Comparative Evaluation of Dasamoolarist, an Ayurvedic Formulation

Kushwaha Ashok1* and Aind Jaya Gladish2

1, Shri RNS College of Pharmacy, Gwalior, MP-India

2, Nimar Institute of Pharmacy, Dhamnod, Dhar, MP - India

Abstract

The present investigation was done to formulate and evaluated dasamoolaristam and compare the efficacy with the brand available in the market as per WHO and Indian Pharmacopoeial specifications. Various physicochemical parameters such as alcohol-soluble extractive, water-soluble extractive, total ash, acid-insoluble ash, total solid, and alcohol content were determined and compared.

Keywords: Dasamoolarist, Ayurvedic formulation, Evaluation

*Corresponding Author

Introduction

In Ayurvedic aristas, Dasamoolarist is a unique combination of ten herbs, where 'dasa' means ten and 'moola' means root. These preparations are regarded as valuable therapeutic formulations due to their efficacy and desirable features. It is a rich tonic that stimulates the nervous system. Dasamoola is a formal combination of ten herbs and has the ability to act on a wide range of health problems; especially those caused by both Vata and Kapha. According to Sarngadhara Samhita, an ancient text, Dasamoolarist "nourishes the lean, stimulates the production of Ojas and gives progeny to the childless." It is an excellent tonic for convalescence and general debility. It helps you to restore health and vitality. It is also recommended for cardiac disorders, respiratory diseases, asthma and breathing troubles, cough, pneumonia, gastric irritation and anemia. It is curative for health problems caused by Vata and Kapha. This is a significant tonic effective in nerves and body weakness, loss of appetite, colic abdominal pain and disorders of emaciation. Dasamoolarist is also widely recommended for cardiac disorders, respiratory diseases, asthma and breathing troubles, cough, pneumonia, gastric irritation and anemia. It is also mixed with other arishtas and used for certain diseases.1

They are generally prepared by soaking the drug, either in powdered form or in the form of decoction (Kasaya), in a solution of sugar or jaggery, for a specified period of time. During this period, the preparation undergoes a process of fermentation to generate alcohol, thus facilitating the extraction of the active principles contained in the drugs. The quality control parameters of herbal formulations are of great importance in order to justify their acceptability in modern systems of medicine. Herbal formulations available in the market are usually not properly standardized and are not assessed for their quality. Since, the use of herbal formulations by patients is increasing, there is an urgent need for pharmacists and physicians to have knowledge about the safety and efficacy of these preparations.2-3 Keeping these thing in mind the present was undertaken to formulate and evaluate dasamoolarist and to compare its efficacy with the brand available in the market.

Material and methods

Different herbs used in the preparation were purchased and collected from the villagers and tribal of Madhya Pradesh and were authenticated by Head, Department of Pharmacognosy of our institute.  Brand of dasamoolarist was purchased from the Ayurvedic Pharmacy, Gwalior. The samples was stored in the refrigerator at 8ºC and collected for experiments under aseptic conditions. All physical evaluations were determined as per the method prescribed in the Indian Pharmacopoeia.4-5

Results and conclusion

The present investigation was aimed to formulate and evaluate dasamoolarist and compare it from the marketed brand. The physical and physiochemical parameters such as pH, total solid content, water-and alcohol-soluble extractive, and alcohol content were determined using standard pharmacopoeial methods. The various evaluation parameters are mentioned in table 1. Alcohol percentage (v/v) was tested and was found within the range. The alcohol content (12%) was found in brand and the (7%) in formulated preparation. The results thus highlighted that the levels of alcohol in were lower than those in fortified wines and distilled spirits. The total alcohol content for all the brands was under the acceptable limit. Thus, in the present investigation, the quality of formulated with that of brand preparation were assessed. Hence, the present findings have shown that the alcohol content of both the formulation were in the acceptable limit of alcohol content as compared to Pharmacopoeial specifications.

 

Table 1: Comparative Physical evaluation of dasamoolarist

 

S/No.

Parameter

Formulated

Branded

1.

pH

3

2.9

2.

Total solid content (% w/v)

20.72

22.89

3.

Alcohol content (% v/v)

7

12

4.

Water-soluble extractive (% w/w)

9.81

11.60

5.

Alcohol-soluble extractive (% w/w)

8.20

9.55

 

References

  1. Kokate C.K., Purohit A.P. and Gokhale S.B. (2005). A Text-book of Pharmacognosy, 31st edition, Nirali Prakashan
  2. Dwivedi Sumeet and Dwivedi Abhishek (2010). Need of standardization of Ayurvedic herbs: Present status and future prospects; Abstract in National Seminar on Analytical Method Development and Biomedical Analysis, organized by B.R.Nahata College of Pharmacy, 28-29.Oct.2010, Mandsaur, M.P.
  3. Dwivedi Sumeet and Dubey Raghvendra (2009). QC of Herbals with special reference to standardization parameters: An overview; Abstract in National Seminar on Technological and Regulatory aspects of Herbal Drugs Analysis, 7-Oct.,2009, Mandsaur, M.P.
  4. Guidelines for the Assessment of Herbal Medicines (1991). Document No. WHO/TRM/91.4, World Health Organization, Geneva.
  5. Ayurvedic Formulary of India (2003). Central Council for Research for Ayurveda and Siddha, 2 Edn., Part 1, Ministry of Health and Family Welfare, Government of India, 3. nd