Stroke is one of the top three leading causes of death worldwide and an area of high unmet needs. TPA is limited to a low number of ischemic stroke patients due to a short therapeutic time window, but it is still the best therapy available. TPA is responsible for major changes and advances in the way stroke patients are cared for, which is expected to evolve further.
The incidence of stroke has been slowly declining over the last 50 years, as well as mortality from stroke. However, stroke continues to be a major public health concern, being the third leading cause of death in the US after heart disease and cancer, and the leading neurologic cause of long-term disability.
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