Unique Biotechnology Platform for Manufacture of Chiral Chemiclas

Farmavita offers development and scale-up of the bioconversion processes suitable for:

• Synthesis of chiral alcohols
• Kinetic resolution of racemic amines
•  Synthesisof chiral hydroxy esters
• Asymethirc transamination of ketones

Exmaple of the technology platform applications:

Biocatalythic method for the synthesis of (S)-(+)-zopiclone

• enzymatic resolution of a carbonate intermediate (±)–2b, via Candida antarctica lipase B-catalyzed hydrolysis

• (R)-configured product 1 of the enzymatic reaction undergoes spontaneous racemization in the reaction medium. Therefore, it can be directly recycled after work-up of the enzymatic reaction.

  Overall formal yield of the enzymatic process is 100 %

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