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Thursday
Nov 20th
Chiral Chemicals Print E-mail

Unique Biotechnology Platform for Manufacture of Chiral Chemiclas

Farmavita offers development and scale-up of the bioconversion processes suitable for:

  • Synthesis of chiral alcohols
  • Kinetic resolution of racemic amines
  •  Synthesisof chiral hydroxy esters
  • Asymethirc transamination of ketones

Exmaple of the technology platform applications:

Biocatalythic method for the synthesis of (S)-(+)-zopiclone

  • zopicloneenzymatic resolution of a carbonate intermediate (±)–2b, via Candida antarctica lipase B-catalyzed hydrolysis

 

  • (R)-configured product 1 of the enzymatic reaction undergoes spontaneous racemization in the reaction medium. Therefore, it can be directly recycled after work-up of the enzymatic reaction.

  Overall formal yield of the enzymatic process is 100 %

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3.20 Copyright (C) 2007 Alain Georgette / Copyright (C) 2006 Frantisek Hliva. All rights reserved."

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