A Novel Means of Greatly Extending Lifespan and Resistance to Oxidative Stress

Ten fold increase in lifespan is observed for the deletion of a single gene

The findings in C. elegans are that the deletion of a specific domain of the phosphoinositol-3-kinase (PI3K) gene results in a 10-fold increase in life span.

This pathway, and this gene, is known to limit lifespan on C. elegans and, with lesser evidence, thought to affect life span in dipteran insects and mammals. The significance of the PI3K deletion rather than the mutations affecting the gene opens novel opportunities for impacting life span.

Current studies implicate the elimination of residual inositol-3,4,5-kinase activity as a possible key factor, and also suggest other directions for investigation that may lead to improvements beyond those within our ability to genetically or pharmacologically extend life span.

Ongoing research seeking insight into the utilization of these findings.

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