|Natural Products for Arthritis Treatment|
|Life Sciences - Life Science Article|
Natural products as a gold mine for arthritis treatment
Arthritis, an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and interleukin-1b) and pro-inflammatory enzymes that mediate the production of prostaglandins (e.g. cyclooxygenase-2) and leukotrienes
The whole 8 pages article is available for download at Downloads section of Farmavita.Net.
Numerous agents derived from plants can suppress these cell signaling intermediates, including curcumin (from turmeric), resveratrol (red grapes, cranberries and peanuts), tea polyphenols, genistein (soy), quercetin (onions), silymarin (artichoke), guggulsterone (guggul), boswellic acid (salai guggul) and withanolides (ashwagandha). Indeed, several preclinical and clinical studies suggest that these agents have potential for arthritis treatment. Although gold compounds are no longer employed for the treatment of arthritis, the large number of inexpensive natural products that can modulate inflammatory responses, but lack side effects, constitute ‘goldmines’ for the treatment of arthritis.
Although there are more than 100 different kinds of arthritides, the three most common in the Western world are gout, osteoarthritis (OA) and rheumatoid arthritis (RA).
Gout occurs in response to the presence of monosodium urate (MSU) crystals in joints, bones and soft tissues, and is usually treated by non-steroidal anti-inflammatory drugs (NSAIDs), oral or intravenous colchicines, and oral, intravenous or intrarticular glucocorticoids. All can abort acute attacks, but they also may have severe side effects.
OA results from articular cartilage failure induced by a combination of genetic, metabolic, biochemical and biomechanical actors. OA is normally treated with analgesics such as acetaminophen and opioids, NSAIDs, and intraarticular herapies such as glucocorticoids and hyaluronans.
In RA, 75% of the sufferers are women, suggesting the importance of hormones in the etiologoy of the disease.Smoking and stress are also thought to contribute to this disease, which is characterized by joint stiffness and swelling, often in a symmetrical pattern on both sides of the
The whole 8 pages article is available for download at Downloads section of Farmavita.Net.Read also at Pharmaceutical Licensing Network
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