Member Area

Farmavita.Net - Pharmaceutical Licensing Network

Tuesday
Sep 02nd
Polymers Print E-mail
Life Sciences - Life Science Article

corn_by_trimmer_741.jpg

POLYMERS FOR DRUG DELIVERY SYSTEM: A REVIEW

Pharmaceutical invention and research are now increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimizing side effects. Drug delivery systems, ranging from implantable electronic devices to single polymer chains, are required to be compatible with processes in the body (biocompatibility) as well as with the drug to be delivered. DDS alter the bio-distribution and pharmacokinetics of the associated drug: that is the time-dependent percentage of the administered dose in the different organs of the body. There are various natural and synthetic polymers are used in drug delivery system. The present communication focuses all these aspects with emphasizes of various polymers used in various drug delivery systems.

The whole 12 pages article is available for download at Downloads section of Farmavita.Net.  

Humankind’s efforts to confront disease dates back to early civilization. Substances taken from nature were tested and used to treat dysfunctions of physiological life processes, pain and discomfort. With the advancement of science, the active ingredients of these materials, the drugs, were identified, isolated and their mechanism of action elucidated. Drug activity is a result of molecular interaction(s) in certain cells & therefore it is necessary for the drug to reach somehow the site of action following administration (oral, intravenous, local, transdermal, etc.) at sufficient concentrations. The scientific field dealing with this issue is known as drug delivery and has essentially the following aim: to deliver the drug at the right place, at the right concentration for the right period of time. When this is impossible by simply selecting an appropriate administration route, or if such administration causes patient discomfort, strategies based on the association of the drug with a carrier (a drug delivery system – DDS) are an alternative.

Pharmaceutical invention and research are now increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimizing side effects. Carrier-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue, cell or intracellular compartment, the control over release kinetics, the protection of the active agent or a combination of the above.

Drug delivery systems, ranging from implantable electronic devices to single polymer chains, are required to be compatible with processes in the body (biocompatibility) as well as with the drug to be delivered. DDS alter the biodistribution and pharmacokinetics of the assosciated drug: that is the time-dependent percentage of the administered dose in the different organs of the body. Furthermore, obstacles arising from low drug solubility, degradation (environmental or enzymatic), fast clearance rates, non-specific toxicity, inability to cross biological barriers, just to mention a few, may be addressed by DDS.
 
The whole 12 pages article is available for download at Downloads section of Farmavita.Net.  
Comments
Search RSS
Only registered users can write comments!

3.26 Copyright (C) 2008 Compojoom.com / Copyright (C) 2007 Alain Georgette / Copyright (C) 2006 Frantisek Hliva. All rights reserved."

Read also at Pharmaceutical Licensing Network
Related News
Newer news items
Related Items
Farmavita.Net - The Pharmaceutical Licensing Network




Reddit!Del.icio.us!Google!Live!Facebook!Slashdot!Netscape!Technorati!StumbleUpon!Newsvine!Furl!Blogmarks!Yahoo!Ma.gnolia!FeedMeLinks!Free social bookmarking plugins and extensions for Joomla! websites!
 
< Prev   Next >
Advertisement
  • Networking Tips & Tricks

    Making Contacts

    Use People Finder tool from Members Manu to find other users.  Form their profile page you can send them message by means of internal messaging system. 

     
  • Latest Published
 

Featured Partners

 
150x150cancer.jpg
bals_150x150_anim.gif 
150-150payers.jpg  
pharmaccess14b_150x150.gif 
medaff14b_150x150.gif
bals150_150x150.gif 
150x150copd.jpg 
2014-pmr-eur-banner-150x150.gif  
2015-pmr-banner-150x150.gif 

Login to Farmavita.Net

membership is FREE

Follow us on:




Join our LinkedIn Group

BabelFish Translator




Click Flag for Translation

Who's Online

We have 166 guests online

Farmavita.Net RSS News


Reports

rbdl0002_innovations-in-inj.gif 

Events

pc_150x150.gif

Reports

rbhc0264_privatehealthcare.gif 

REPORTS

farmavita_research-store.gif