|Life Sciences - Life Science Article|
|Written by R.Margret Chandira|
|Monday, 25 May 2009|
FORMULATION AND EVALUATION OF FLOATING TABLETS OF CEFUROXIME AXETIL
The aim of the present work was to design and development of hydrodynamically balanced tablet of cefuroxime axetil to enhance the bioavailability and therapeutic efficacy of the drug. Cefuroxime axetil is classified as a second-generation cephalosporin antibiotic and beta lactum antibiotics based on spectrum activity. Tablets are prepared by the direct compression technique by using HPMC K4M and mannitol as polymers along with sodium bi carbonate as gas generating agent. Formulation were evaluated for in vitro byoyancy and drug release study using up dissolation apparatus using 0.1N Hcl as a medium.The result indicate that floating tablets of dissolation cefuroxime axetil containg 45mg HPMC K4M provides a better option for control release action and improved bioavailability.
The whole 8 pages article is available for download at Downloads section of Farmavita.Net
The design of oral controlled drug delivery systems (DDS) should be primarily aimed to achieve more predictable and bioavailability. Approximately 50% of the drug delivery systems available in the market are oral DDS and these systems have more advantages due to patient acceptance and ease to administration. Gastric retention drug delivery systems can be retained in the stomach for a long time. Such retention systems are important for drugs that are degraded in intestine or for drugs like antacids or certain antibiotics.
Cefuroxime axetil is classified as a second generation cephalosporin antibiotic and cefuroxime axetil beta lectum antibiotics based on spectrum of activity. In the present work by developing hydrodynamically balanced system or floating drug delivery system which increases the gastric residence time, decreases the diffusion distance and allow more of antibiotic to penetrate through the gastric mucus layer and act locally at the infectious site. The present study outlines a systemic approach for design and development of hydrodynamically balanced tablets cefuroxime axetil to enhance the bioavailability and therapeutic efficacy of the drug.
The whole 8 pages article is available for download at Downloads section of Farmavita.NetRead also at Pharmaceutical Licensing Network
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