|Continous Oral Drug Delivery|
|Life Sciences - Life Science Article|
|Written by Margret Chandira|
|Tuesday, 21 April 2009|
EMERGING TRENDS OF ORAL CONTROLED DRUG DELIVERY SYSTEMS-AN OVERVIEW
Oral controlled release drug delivery is a drug delivery system that provides the continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either a local or systemic action. All the pharmaceutical products formulated for systemic delivery via the oral route of administration, irrespective of the mode of delivery (immediate, sustained or controlled release) and the design of dosage form (either solid, dispersion or liquid), must be developed within the intrinsic characteristics of GI physiology. Therefore the scientific framework required for the successful development of an oral drug delivery systems consists of basic understanding of (i) physicochemical, pharmacokinetic and pharmacodynamic characteristics of the drug; (ii) the anatomic and physiologic characteristics of the gastrointestinal tract and (iii) physicochemical characteristics and the drug delivery mode of the dosage form to be designed.
The whole 25 pages article is available for download at Downloads section of Faramavita.Net
Challenges of Oral Control Drug Delivery Systems
The main areas of potential challenge in the development of oral controlled drug delivery systems are:
Controlled Drug Delivery Systems
Conventional oral controlled dosage forms suffer from mainly two adversities. The short gastric retention time (GRT) and unpredictable gastric emptying time (GET). A relatively brief GI transit time of most drug products impedes the formulation of single daily dosage forms. These problems can be overwhelmed by altering the gastric emptying. Therefore it is desirable, to formulate a controlled release dosage form that gives an extended GI residence time.
The whole 25 pages article is available for download at Downloads section of Faramavita.NetRead also at Pharmaceutical Licensing Network
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