Pharmaceutical Company Outlook to 2014

PharmaVitae universe Rx sales are forecast to expand at a 2008-14 CAGR of 1.2%, down 9.3 percentage points from 2002-08. The underlying cause of this falling rate is the much-discussed genericization of small molecule products. However, not all sectors are equally exposed, prompting a shake-up of the industry and an increasing pursuit of cost savings to sustain operating profit growth rates.

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Cost containment and M&A shape the global generics industry

This report analyses both quantitatively and qualitatively the unbranded generics industry, the Top 10 generics companies by unbranded generics sales, the Top five therapy areas and the major North American, European, Asia Pacific and Latin American markets.

Generics Overview in the Seven Major Markets

Increasing generics volume uptake will provide much needed cost-savings in the less mature markets of France, Italy, Spain, and Japan, and requires regulators to incorporate effective utilization incentives for key stakeholders. While volume will grow in the US, Germany, and the UK, regulators are increasingly looking to capture value from generics by pushing down price and speeding market access.

US and EU regulators close in on pharmaceutical pay-for-delay deals

The evolving relationship between branded and generics pharmaceutical companies is set to undergo considerable change as regulators in both the US and EU move to restrict 'pay-for-delay' deals in a bid to increase generics cost-savings. As deals that delay the market entry of generics come under increasing scrutiny, the industry may find that its best option is to cease such practices altogether.

Europe Picture Archiving and Communication Systems (PACS) Market: Market Analysis and Opportunity Assessment

GlobalData's "Europe Picture Archiving and Communication Systems (PACS) Market: Market Analysis and Opportunity Assessment" report is an essential source of data and analysis on the Europe PACS market. The report provides market landscape, competitive landscape and market trends information on the Europe PACS market. The report identifies the key trends shaping and driving the dynamism in the Europe PACS market. The report also provides insight on the prevalent competitive landscape and on the emerging players which are expected to bring significant shift in the market standing of the existing leaders. The report also provides valuable insight on the pipeline products within the Europe PACS market.

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US Surgical Sutures Market: Surgical Procedures Growth to Drive Demand

GlobalData's "US Surgical Sutures Market: Surgical Procedures Growth to Drive Demand" report is an essential source of data and analysis on the US surgical sutures market with complete coverage by categories. The report provides market landscape, competitive landscape and market trends information on two market categories - absorbable sutures and non absorbable sutures. The report identifies the key trends shaping and driving the dynamism in the US surgical sutures market. The report also provides insight on the prevalent competitive landscape and on the emerging players which are expected to bring significant shift in the market standing of the existing leaders. The report also provides valuable insight on the pipeline products within the US surgical sutures market.

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ANTI-DIARRHEAL ACTIVITY OF ETHANOLIC EXTRACT OF CALOTROPIS PROCERA R. Br. ROOTS

Calotropis procera R. Br. (Asclepidaceae) is a shrub which widely distribute in the world. The plant is used in the treatment of many disease and disorder both in humans and veterinary application. The present work was undertaken to investigate the anti-diarrhoeal activity of ethanolic extract of root (200 mg/kg BW) of Calotropis procera against castor oil induced diarrhoea in experimental animal and was found to be significant results.

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Sanofi-Aventis: CNS franchise takes a knock

Sanofi-Aventis has withdrawn its US and EU applications for its insomnia candidate, eplivanserin. Previously posited by Datamonitor to emerge as a key player in the insomnia market, the drug's discontinuation represents a blow to Sanofi-Aventis' diminishing late-stage CNS pipeline. The company's decision also casts doubt on the future of the serotonergic drug class in the treatment of insomnia.

Sanofi-Aventis: PharmaVitae Profile

This analysis examines the historical and forecast performance for Sanofi-Aventis in the pharmaceutical sector.

A NEW METHOD FOR THE DEVELOPMENT OF ESCHERICHIA COLI RESISITANT AGAINST ANTIBIOTIC AMPICILLIN

Bacteria are like living paint, covering nearly every surface imaginable and living within a variety of living and nonliving things. An antibiotic is any substance produced by a microorganism, which harms or kills another microorganism. However, antibiotics do not harm viruses. A majority of antibiotic substances are natural products that certain bacteria and fungi produce as a natural defense to send outside their cells.

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The Evolving Pharma M&A Landscape: Emerging trends and predicted post-blockbuster targets

The report identifies the factors responsible for growing pressure on leading pharmaceutical businesses and strategic responses being pursued by the industry. It includes a critical appraisal of mega-mergers triggered by similar factors in the past, and an analysis of the two mega-mergers that have been announced since the beginning of 2009.

Development and evaluation of controlled release mucoadhesive tablets of Tramadol Hydrochloride

The present investigation concerns the development of mucoadhesive tablets of Tramadol Hydrochloride which were designed to prolong the gastric residence time after oral administration. Tablets of Tramadol Hydrochloride were formulated using four mucoadhesive polymers namely guar gum, xanthan gum, HPMC K15M and HPMC K100M and carried out studies for its evaluation parameters. Formulations F15 and F16 containing polymers of Xanthan gum, HPMC K100M and HPMC K15M were established to be the optimum formulation since it shows optimum bioadhesive force, swelling index & desired evaluation standards. Further investigations are needed to confirm the in vivo efficiency, long term stability studies are needed to stabilize the controlled released formulations.

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RECENT APPROACHES IN MICROSPHERES: A NOVEL DRUG DELIVERY SYSTEM

Microsphere technology has been studied extensively for the sustained delivery of therapeutic agents. Microspheres can be manufactured from various natural and synthetic materials. Glass microspheres, polymer microspheres and ceramic microspheres are commercially available. Recent researches are confined to the discovery of active microspheres in the treatment of cancers. The present paper review the recent approaches in microspheres technology, a novel drug delivers system.

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ESTIMATION OF MICROBIAL LIMITS IN OILS

Oil is an important source of fat and is important in human diet. The microbial limit tests are designed to perform the qualitative and quantitative estimations of specific viable microorganisms present in pharmaceutical substances or in the samples. The present paper deals with the various procedures in estimation of microbial limits in oils.

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RECENT ADVANCES IN DIFFERENT ASPECTS OF TABLET COATING

Coated tablets are defined as tablets covered with one or more layers of mixture of various substances such as natural or synthetic resins ,gums ,inactive and insoluble filler, sugar, plasticizer, polyhydric alcohol, waxes, authorized colouring material and some times flavoring material. Coating may also contain active ingredient. Substances used for coating are usually applied as solution or suspension under conditions where vehicle evaporates. The present paper reviews recent advances in different aspects of tablet coating.

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Colorectal Cancer - Growing trend towards personalized medicine

CRC incidence will be over 490,000 cases by 2018 in the seven major markets. This large patient base will translate into a high commercial potential for the development of novel, more effective therapies. Currently, there are 77 agents in development for CRC, 4 of which are in late-phase development. Collectively, they are forecast to achieve sales of $1,398m by 2018.

Genentech/Roche: UK's NICE remains negative over Avastin for colorectal cancer

NICE, the UK's cost effectiveness watchdog, has again rejected the use of Avastin in combination with chemotherapy for first-line colorectal cancer patients, arguing that the drug isn't a cost effective use of NHS resources. Limited access to Avastin in the NHS will allow Erbitux to further penetrate the first-line colorectal cancer market in the UK, for which it was approved earlier this year.

New Multi-Marketing Channel Strategies

The future of Pharma marketing lies in using new marketing channels such as social media intertwined with traditional marketing practices to create a multi-channel marketing mix. However, online brand promotion through social media is more effective for targeting patients than physicians, indicating direct marketing tactics to physicians through social media should be limited.