The term ‘Sustained Release' is known to have existed in the medical and pharmaceutical literature for many decades. Sustain release has been constantly used to retard the release of therapeutic agent such that its appearance in the circulation is delayed and/or prolonged and its plasma profile is sustained in duration. The onset of its pharmacological action is often delayed and duration of therapeutic action is sustained.
The object of sustain release of drug, in a general way is to modify the normal behaviour of drug molecule in a physiological environment. It can lead to the following.
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