Liposomal Drug Delivery System Download

Description:

EMERGING TRENDS OF LIPOSOMES USED AS NOVEL DRUG DELIVERY SYSTEM

Drug delivery systems (DDS) have become important tools for the specific delivery of a large number of drug molecules. Since their discovery in the 1960s liposomes were recognized as models to study biological membranes and as versatile DDS of both hydrophilic and lipophilic molecules. Liposomes can be used as carrLiposomes--nanosized unilamellar phospholipid bilayer vesicles--undoubtedly represent the most extensively studied and advanced drug delivery vehicles. After a long period of research and development efforts, liposome-formulated drugs have now entered the clinics to treat cancer and systemic or local fungal infections, mainly because they are biologically inert and biocompatible and practically do not cause unwanted toxic or antigenic reactions. A novel, up-coming and promising therapy approach for the treatment of solid tumors is the depletion of macrophages, particularly tumor iers for both water and lipid soluble agents. Substances entrapped in liposome's include enzymes, glycolipids, immunoglobulin, monoclonal antibiotics, drugslike antitumour, antiarthiritic and antiparasitic, antigens, antifungal agents, antibiotics and chromosomes. Liposomes are artificial phospholipids bilayer vesicle. Liposomes are chiefly composed of natural or synthetic phospholipids especially lecithins hence can be metabolized in vivo and are generally non-toxic and no-antigenic. Entrapment of drug leads to different pharmacokinetics hence can result in better therapeutic index and enhanced cellular uptake. Thus the ADME of the agent can be altered by manipulating the physicochemical properties of liposomes, instead of the drug.

 

 

Submitted On:

05 May 2009

Submitted By:

Martina Ivanisevic (Martina)

File Date:

05 May 2009

File Author:

Debjit Bhowmik

File Size:

383.85 Kb

File Type:

pdf

Downloads:

79

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