QSAR study on benzimidazole derivatives using several topological and indicator descriptors was performed and evaluated for their antibacterial activities. The correlation equations of these relationships which were designed according to the Hansch Analysis Method were given. The 5 best models were selected for the discussion. Initial regression analysis indicated that balaban index plays a dominating role in modeling the activity in all proposed models. Results are interpreted on the basis of multiple regression and cross-validation methodology. Furthermore, the domain of applicability which indicates the area of reliable prediction is defined.
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