Tramadol Hydrochloride Download

Description:

Development and evaluation of controlled release mucoadhesive tablets of Tramadol Hydrochloride

The present investigation concerns the development of mucoadhesive tablets of Tramadol Hydrochloride which were designed to prolong the gastric residence time after oral administration. Tablets of Tramadol Hydrochloride were formulated using four mucoadhesive polymers namely guar gum, xanthan gum, HPMC K15M and HPMC K100M and carried out studies for its evaluation parameters. Formulations F15 and F16 containing polymers of Xanthan gum, HPMC K100M and HPMC K15M were established to be the optimum formulation since it shows optimum bioadhesive force, swelling index & desired evaluation standards. Further investigations are needed to confirm the in vivo efficiency, long term stability studies are needed to stabilize the controlled released formulations.

Submitted On:

14 Dec 2009

Submitted By:

Martina Ivanisevic (Martina)

File Date:

14 Dec 2009

File Author:

R. Margret Chandira

File Size:

386.06 Kb

File Type:

pdf

Downloads:

21

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Total Votes:0

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